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Study finds no evidence that CBD reduces the negative effects of cannabis

Nov 16, 2022 | Media Partners, The GrowthOp

This post is presented by our media partner The Growth Op
View the original article here.

‘None of the CBD levels studied protected our volunteers from the acute negative effects of cannabis, such as anxiety, psychotic symptoms, and worse cognitive performance’

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A new study out of King’s College London has found no evidence that cannabidiol (CBD) reduces the negative effects of cannabis.

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Results of the randomized and double-blind trial were published in Neuropsychopharmacology, and challenges the belief that CBD can protect consumers from psychotic experiences and memory problems, reports Neuroscience News.

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  1. One reductive consensus you might hear is that CBD contains all the good therapeutic value of cannabis, while THC includes virtually known and only benefits those who want to get high.

    Marijuana study: THC could have more medical value than CBD

  2. Research suggests that certain receptors drive the brain’s reward system and promote further drug-seeking. /

    Cannabis holds promise for pain management, reducing the need for opioid painkillers. A neuropharmacology expert explains how

  3. Research suggests that certain receptors drive the brain’s reward system and promote further drug-seeking. /

    CBD used to treat young people with treatment-resistant anxiety shows ‘amazing’ results

The study involved 46 healthy volunteers who inhaled cannabis vapour containing 10mg of THC and CBD ranging from 0 mg, 10 mg, 20 mg or 30 mg.

Researchers found that altering the dose of CBD did little to deter the detrimental effects of THC, including the affect cognitive performance and psychotic symptoms.

“None of the CBD levels studied protected our volunteers from the acute negative effects of cannabis, such as anxiety, psychotic symptoms, and worse cognitive performance. It also did not change the quality of the intoxication in any way,” lead author Amir Englund said in a news release

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Last year, a study published in the Journal of Clinical Psychopharmacology found that when CBD was consumed alongside THC it lowered psychotomimetic scores in subjective scales when compared with THC alone.

“This study provides evidence for both the psychotomimetic effects of THC and the anti-psychotomimetic effects of CBD when it is coadministered with THC in real-world situations, which can be very relevant for the clinical practice of medical cannabis,” researchers concluded.

In 2019, a study out of the University of Western Ontario examined how CBD can offset the psychiatric side-effects of THC. In an animal study, researchers investigated the role of a molecule in the brain’s hippocampus called extracellular-signal regulated kinase (ERK) which triggers the neuropsychiatric effects of THC, reports SciTechDaily.

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“For years we have known that strains of cannabis high in THC and low in CBD were more likely to cause psychiatric side-effects,” said researcher Steven Laviolette, a professor at Western’s Schulich School of Medicine & Dentistry. “Our findings identify for the first time the molecular mechanisms by which CBD may actually block these THC-related side-effects.”

Researchers also found that CBD alone had no effect on the ERK pathway but CBD and THC consumed together “completely reversed the direction of the change on a molecular level. CBD was also able to reverse the anxiety-like behaviour and addictive-like behaviour caused by the THC.”

For his part, Englund added that it “may still be safer for users to choose cannabis with higher CBD: THC ratios.”

We’d love to hear from you. Get in touch with feedback and story tips at thegrowthop@postmedia.com

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