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Study Finds That Psilocybin’s Therapeutic Effect Isn’t Altered by SSRI Medication

Jan 4, 2022 | Media Partners, Psychedelic News Wire

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Compass Pathways recently released data that shows that selective serotonin reuptake inhibitor (“SSRI”) drugs can be used together with psilocybin. SSRI drugs are commonly used to treat mental health conditions including anxiety and depression.

Estimates show that more than 300 million individuals globally suffer from major depressive disorder, with about one-third of that population not getting finding any help or relief from current therapies.

Compass is carrying out a trial for its COMP360 psilocybin formulation, which involves patients on SSRI therapy being administered with one 25 mg dose of its therapeutic formulation. The study found that the treatment outcomes in patients who stopped using SSRI drugs before beginning psilocybin therapy were similar to those who continued to use the prescribed medication while on psilocybin therapy.

Compass chief medical officer Guy Goodwin stated that the results of the trial challenged the belief that using SSRI drugs in conjunction with psilocybin could interfere with the therapeutic effect of the psychedelic drug. He explained that the study’s findings offered evidence that the COMP360 therapy could be used as a monotherapy as well as a complementary treatment to SSRI medication.

In addition to this, the study found that the psilocybin therapy was well tolerated when administered at the same time as the patient’s SSRI medication. Researchers note that there were no severe treatment-emergent adverse events associated with suicidal behavior or ideation nor was self-injury observed.

This study is important, especially for the emerging psychedelics space, because research has shown that mental health conditions would be more effectively treated with the use of psychedelics such as LSD, DMT, ketamine, MDMA and psilocybin.

Compass Pathways is anticipating its meeting with the FDA which is scheduled for early next year. It plans to finalize its plans for its phase III trial, which it hopes will commence by the third quarter of next year.

The new data was released only a few weeks after Mind Medicine (NASDAQ: MNMD) (NEO: MMED) (“MindMed”), another psychedelic medicine biotech firm, released data showing that the use of escitalopram, an SSRI medication, had no impact on psilocybin’s positive mood effects. The study was conducted by researchers at the University Hospital Basel Liechti Lab, who discovered that pretreatment with the SSRI drug didn’t modify psilocin’s pharmacokinetics. Psilocin is the active compound found in psilocybin.

In the report, Dr. Matthias Liechti, the principal investigator for the MindMed study, noted that the study’s findings showed that psilocybin could be administered during treatment with escitalopram without altering psilocybin’s effects.

Many other companies, including Delic Holdings Corp. (CSE: DELC) (OTCQB: DELCF), are also engaged in their own research and development work with the aim of bringing to market psychedelic medicines indicated for various mental health conditions. These companies hope the time will come soon that the world can look forward to a variety of effective mental health condition remedies being readily available to those who need them.

NOTE TO INVESTORS: The latest news and updates relating to Delic Holdings Corp. (CSE: DELC) (OTCQB: DELCF) are available in the company’s newsroom at

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