Victoria, BC

Join us on Vancouver Island in majestic Victoria, BC for 3 days of cannabis cultivation and extraction.

June 20-22, 2022

Niagara Falls, ON

Join us in spectacluar Niagara Falls, ON for 3 days of cannabis cultivation and extraction.

September 12-14, 2022

Grow Up Awards Gala

Annual Grow Up Industry Awards. Come celebrate the innovation and sucess in the cannabis growing industry.

June 20, 2022, Victoria, BC

Study: Using cannabis with prescription drugs could result in ‘a significant risk of harmful drug interactions’

Dec 14, 2021 | Media Partners, The GrowthOp

This post is presented by our media partner The Growth Op
View the original article here.

Metabolites in users’ blood seem to interfere with metabolizing a wide range or prescribed drugs and could result in toxicity or accidental overdose.

Article content

Researchers from Washington State University report that cannabis consumers who also used other drugs to treat various conditions might be reducing the effectiveness of the latter.

Advertisement

Story continues below

Article content

Investigators seeking to determine any possible drug-drug interactions found that the positive effects of the treatment drugs being taken might decrease or their negative effects might increase, explains a statement from the university.

Should too much of the drugs build up in the body, this could spur “unintended side effects such as toxicity or accidental overdose,” researchers explain.

  1. These are the first exemptions to the Controlled Drugs and Substances Act to be granted for mental health reasons by the new Minister of Health, Jean-Yves Duclos. PHOTO BY REUTERS/BLAIR GABLE

    Exclusive: Three Canadians with mental health conditions receive legal access to psilocybin mushrooms

  2. FILE: Military march held in Canada as the body of a fallen soldier was repatriated in September 2009.

    Canadian survey: Anxiety or stress top reason that Canadian veterans report they are turning to medical cannabis

  3. A comparison of the exposed and control groups found that the former, immediately after the exposure period, had decreased sperm motility. /

    Study: Exposure to cannabis vapour adversely affects mice sperm for two generations

To come to that view, investigators looked at cannabinoids — including THC, CBD and CBN — and their major metabolites found in cannabis users’ blood. They used manipulated human kidney cells, thereby allowing “them to look at a single enzyme at a time.”

Advertisement

Story continues below

Article content

According to the university statement, researchers suggest these cannabinoids and metabolites “interfere with two families of enzymes that help metabolize a wide range of drugs prescribed for a variety of conditions.”

Possible toxicity is a real concern and something that physicians should have on their radars, notes senior author Philip Lazarus.

This is particularly the case when cannabis is being used for medicinal purposes, Lazarus suggests. “It’s one thing if you’re young and healthy and smoke cannabis once in a while, but for older people who are using medications, taking CBD or medicinal marijuana may negatively impact their treatment,” he cautions.

Findings are based on two studies published in Drug Metabolism and Disposition: one focused on the cytochrome P450s (CYPs) family of enzymes, and the other on the UDP-glucuronosyltransferases (UGTs) family of enzymes.

Advertisement

Story continues below

Article content

“Together, these two enzyme families help metabolize and eliminate more than 70 per cent of the most commonly used drugs from the body,” the release states.

Specifically, investigators found that “cannabinoids and the major THC metabolites strongly inhibited several CYP enzymes,” and that “THC-COO-Gluc appears to play a major role in inhibiting several key enzymes in the liver.”

With respect to UGTs, the three aforementioned cannabinoids — but especially CBD — “inhibited two of the primary UGT enzymes present in the liver. CBD was also found to block three enzymes that account for about 95 percent of kidney UGT metabolism, which helps clear toxins and certain drugs from the body,” the statement notes.

“If you have a kidney disease or you are taking one or more drugs that are metabolized primarily through the kidney and you’re also smoking marijuana, you could be inhibiting normal kidney function, and it may have long-term effects for you,” Lazarus cautions.

Advertisement

Story continues below

Article content

Possible toxicity is a real concern and something that physicians should have on their radars. /
Possible toxicity is a real concern and something that physicians should have on their radars. / Photo by Getty Images

Calling the findings the first to show the inhibition potential of THC-COO-Gluc — the most abundant plasma cannabinoid metabolite — researchers write in one of the studies that “major cannabinoids and their metabolites found in the plasma of cannabis users inhibit several P450 enzymes.”

Those enzymes “are involved in the synthesis and metabolism of a range of internal and external cellular components,” according to Medical Life Sciences.

Shamema Nasrin, the study’s first author, says the resulting metabolites created when cannabinoids break down in the body can remain for as long as 14 days and are at higher concentrations than cannabinoids. These are points, Nasrin maintains, that “have been overlooked in previous studies, which is why we thought we should focus on those as well.”

Advertisement

Story continues below

Article content

Study authors cite cannabis legalization in many parts of the U.S. and other countries as highlighting the “need for a more comprehensive understanding of cannabis constituents and their potential for drug-drug interactions.”

As such, the university statement emphasizes that “it’s important to be careful when using cannabis with other prescription drugs.”

“Taking CBD or marijuana might help your pain, but could be making the other drug you’re taking more toxic, and that increase in toxicity may mean that you can’t continue taking that drug,” says Nasrin.

“So, there could be serious ramifications for anti-cancer drugs, and that’s only one example of the many drugs that could potentially be affected by the cannabinoid-enzyme interactions we’re seeing,” she adds.

The authors of an Australian study exploring potential drug interactions with medicinal marijuana would likely agree. “Caution should be undertaken to closely monitor the responses of cannabis users with certain drugs to guard their safety, especially for the elderly and people with chronic diseases or kidney and liver conditions,” write the authors of the study published in 2019.

A review in the Canadian Medical Association Journal last year found that there was an increased clearance of certain drugs among regular cannabis users. That said, “no effect of occasional use has been reported.”

Advertisement

Story continues below

Article content

We apologize, but this video has failed to load.

Subscribe to Weekend Dispensary , a new weekly newsletter from The GrowthOp.

    Advertisement

    Story continues below

    Comments

    Postmedia is committed to maintaining a lively but civil forum for discussion and encourage all readers to share their views on our articles. Comments may take up to an hour for moderation before appearing on the site. We ask you to keep your comments relevant and respectful. We have enabled email notifications—you will now receive an email if you receive a reply to your comment, there is an update to a comment thread you follow or if a user you follow comments. Visit our Community Guidelines for more information and details on how to adjust your email settings.

    This post was originally published by our media partner here.

    UPCOMING EVENTS

    O’Cannabiz – June 1-3, 2022
    International Convention Centre, Toronto ON

    Grow Up – June 20-22, 2022
    Victoria Convention Centre, Victoria ON

    Grow Up – September 12-14, 2022
    Niagara Falls Convention Centre, ON

    News from Grow Up Media partners