by Grow Up Conference | Jun 30, 2023 | Cannabis News Wire, Media Partners
- Lexaria’s latest peer-reviewed publications were published in June 2023 in the International Journal of Molecular Sciences, Advances in Therapy, and Biomedicine & Pharmacotherapy
- Lexaria’s eight peer-reviewed publications support the company’s pursuit of launching an FDA-registered IND program to formally investigate DehydraTECH(TM)-CBD for hypertension
- The global cardiovascular drug market was worth $146.5 billion and is expected to reach $173.5 billion in 2026 – making patent protection crucial in commercial markets
- To date, Lexaria has a robust intellectual property portfolio with 34 patents granted and many more pending worldwide
Lexaria Bioscience (NASDAQ: LEXX), a global innovator in drug delivery platforms, recently announced the publishing of its groundbreaking research utilizing DehydraTECH(TM)-processed cannabidiol (DehydraTECH-CBD) in eight peer-reviewed articles in six different publications. Since 2016, the company’s patented DehydraTECH(TM) technology has repeatedly demonstrated the ability to increase bio-absorption with cannabinoids, antiviral drugs, PDE5 inhibitors, and more.
These publications build on Lexaria’s growing body of peer-reviewed literature developed on the company’s leading research into the effects of DehydraTECH-CBD on human health, including indications such as hypertension. The most recent paper is entitled, “Differences in Plasma Cannabidiol Concentrations in Women and Men: A Randomized, Placebo-Controlled, Crossover Study,” which was published in June 2023 in the International Journal of Molecular Sciences (https://cnw.fm/Fu8ee).
“We’re proud of the impressive amount of research that our company has been able to develop through its HYPER-H21 series of clinical studies that has now been assessed by a variety of our respected peers,” said John Docherty, President of Lexaria (https://cnw.fm/nOa7o). “Lexaria is establishing itself as one of the world’s leaders in the investigation of cannabidiol for the purposes of controlling human blood pressure, and we are now focused on launching an FDA-registered IND program to formally investigate DehydraTECH-CBD for hypertension this year.”
Additional publications include the following, which are also available at PubMed:
- September 2019, “Examination of a New Delivery Approach for Oral Cannabidiol in Healthy Subjects,” published in the journal Advances in Therapy (https://cnw.fm/w7i3j).
- June 2022, “Chronic Effects of Effective Oral Cannabidiol Delivery on 24-h Ambulatory Blood Pressure and Vascular Outcomes in Treated and Untreated Hypertension (HYPER-H21-4): Study Protocol for Randomized, Placebo-Controlled, and Crossover Study,” published in the Journal of Personalized Medicine (https://cnw.fm/jkl3S).
- April 2023, “Trial of a Novel Oral Cannabidiol Formulation in Patients with Hypertension,” published in Pharmaceuticals (https://cnw.fm/aq1ig).
- April 2023, “Chronic Effects of Oral Cannabidiol Delivery on 24-h Ambulatory Blood Pressure in Patients with Hypertension,” published in Cannabis and Cannabinoid Research (https://cnw.fm/P1eMz).
- April 2023, “CBD supplementation reduces arterial blood pressure via modulation of the sympatho-chromaffin system,” published in Biomedicine & Pharmacotherapy (https://cnw.fm/70Nn0).
- June 2023, “The Influence of Oral Cannabidiol on 24-h Ambulatory Blood Pressure and Arterial Stiffness in Untreated Hypertension,” published in Advances in Therapy (https://cnw.fm/g4dQl).
- June 2023, “Effects of CBD supplementation on ambulatory blood pressure and serum urotensin-II concentrations in Caucasian patients with essential hypertension,” published in Biomedicine & Pharmacotherapy (https://cnw.fm/0qIDK).
The global cardiovascular drug market was worth $146.5 billion in 2022 and is expected to reach $173.5 billion in 2026 (https://cnw.fm/n0ti1). By region, North America is the biggest market in the world, making US patent protection necessary in the pursuit of commercial markets. The fields of diabetes and heart disease are broad but emerging markets making them two primary areas of interest for Lexaria – where DehydraTECH-CBD has already generated positive study data. Lexaria operates a licensed in-house research laboratory and holds a robust intellectual property portfolio with 34 patents granted and many more pending worldwide.
For more information, visit the company’s website at www.LexariaBioscience.com.
NOTE TO INVESTORS: The latest news and updates relating to LEXX are available in the company’s newsroom at https://cnw.fm/LEXX
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by Grow Up Conference | Jun 30, 2023 | Cannabis Prospect Magazine, Media Partners
by Grow Up Conference | Jun 30, 2023 | Cannabis Prospect Magazine, Media Partners
by Grow Up Conference | Jun 30, 2023 | Cannabis Prospect Magazine, Media Partners
by Grow Up Conference | Jun 30, 2023 | Media Partners, Psychedelic News Wire
The Colorado Convention Center recently hosted the latest iteration of Psychedelic Science, a massive psychedelic-themed event that attracted thousands of attendees from around the world. Psychedelic Science 2023 was the largest psychedelic conference ever held worldwide, bringing in nearly 12,000 attendees from various walks of life and a host of speakers to talk about recent events and breakthroughs in psychedelics.
Here are the five main takeaways from the fourth Psychedelic Science event;
Psychedelics have caught the eye of a very diverse group of people. The recent conference drew people with a diverse array of backgrounds and interests.mThe exhibition hall, for instance, featured hundreds of vendors with various psychedelic or science-themed products.
Several organizations advertised treatments such as ketamine-assisted therapy, drug-testing kits, and even psychedelics for pets.
People wanted to share their psychedelic experience. Psychedelic trips are often deeply personal experiences that allow people to make profound realizations and insights that they might not have made while sober. Everyone wanted to share their own experiences and it was exceedingly common to hear snippets of random conversations involving taking one psychedelic or the other.
Word of mouth has been one of the most common mediums for passing information about psychedelics, such as one veteran who benefitted from hallucinogens telling another vet about his treatment.
NFL player Aaron Rodgers credited ayahuasca with upping his game. The quarterback told podcaster Aubrey Marcus that using the psychedelic concoction granted him “deeper self-love” and allowed him to improve his performance on the field.
Rodgers noted that before his first experience with ayahuasca in 2020, he had scored 26 touchdowns and made 4 interceptions. In the year after his psychedelic experience, Rodgers made 46 touchdowns and 5 interceptions, and was crowned most valuable player (MVP), a string of feats that he partly attributes to ayahuasca.
Colorado Governor Jared Polis praised his state’s psychedelic framework and said that his state should be the standard for psychedelic policies. Speaking at the Bellco Theater, Polis said Colorado is in the midst of implementing the ballot measure that decriminalized certain psychedelics in 2022.
Furthermore, Polis said that Colorado should copy policies from its cannabis industry and expunge the records of individuals with certain psychedelic-related convictions.
Former Texas Governor Rick Perry expressed support for psychedelics. The Republican revealed that he started supporting psychedelic reform after seeing a family friend fail to find a cure for PTSD after serving as a Navy SEAL in Afghanistan. After nearly every conventional method of treatment, the Navy Seal turned to psychedelic-assisted treatment and saw overwhelmingly positive results. This changed Perry’s opinion on psychedelics and put him firmly on the side of researching psychedelics for their potential medical benefits.
As these stories of people who have benefited from using psychedelics continue to proliferate, the hope that enterprises such as Compass Pathways PLC (NASDAQ: CMPS) make breakthroughs and bring to market safe psychedelic-based treatments will keep increasing in the public as patients would prefer regulated medicines as opposed to self-prescribed psychedelic use.
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by Grow Up Conference | Jun 30, 2023 | Grow Opportunity, Media Partners
Most days were the same. Open up the doors to have three or four of the same regulars saunter in, casually browsing before making roughly the same purchase they had made the day before. At that hour, you’re guaranteed to have your chronic customers – the window shoppers and dabblers don’t show up until around 3pm.
Half of my job was getting people in and out the door as fast as we could, and the other half was education. It never occurred to me that when applying for this job, it would lead to feeling so fulfilled in a retail setting. The ability to educate about cannabis and its benefits for a wide variety of ailments, while being careful not to give any medical advice, took up most of my time with prospective users.
Rarely did a customer ever discuss trichomes or genetics unless they came in to show off their knowledge, of which I would cherry pick the gems and pass them onto other clientele.
Our elderly customers would come in for a sleep aid or for pain management, and a consistent story began appearing with these folks: “I’ve got this terrible pain and I’m on (two or three prescriptions). Do you have anything you can recommend that won’t make me high?”
I’ve got to say, compared to working at the liquor store when I was younger, it’s neat being a legal drug dealer and interacting with much happier customers. At a liquor store, pointing out who’s the alcoholic is pretty evident. As for the chronic weed smokers, they are much more upbeat, and their physicality appears to be in better shape.
As for the store I worked at, I will say it was certainly not an… inspired experience. But I loved my customers and co-workers. It was our job to sling bud and build an engaging atmosphere for people when they came in, which we were consistent with, seeing as how we needed to install a bench for our customers to sit down and chat (upon which many a chat was had!)
That being said, the management and corporate management of our company was run by people who you could tell didn’t have as much compassion for people. From a business perspective, I understand the need to be profit-oriented, but it should never come at the cost of the cool atmosphere created and maintained in the pot shop; that is why the people came.
Staff were pleasant, the layout was beautiful without being busy or overcrowded, and our prices were comparable if not better than our competition across the street.
If the opportunity arose to educate someone on the benefits of cannabis, it was almost always met with a “thank you” and subsequent purchase.
The cannabis industry is relatively simple on the retail side when it comes to customers. I mean if they are walking in the door, chances are the purchase has already been made in their head and you just have to close the deal. But be on the lookout for the not-so-confident person who wanders in out of curiosity. With kind words and earnest listening, as many are interested in being heard, they’re sure to become a repeat customer.
Honestly, it’s Vancouver Island, where everyone and their dog is selling weed. So, the best method I saw for capturing the sale, and future sales, is consistency. Consistency of product, but most importantly, I feel, is consistency from the budtenders in terms of knowledge and attitude towards the public.
Questions to consider:
Maybe as an industry we should be collectively asking ourselves this: Does securing this kind of talent require a raise in pay grade? Should more samples and perks be afforded to those behind the counter? Would better rapport between growers and retail be effective for the purposes of tackling the legacy market?
How many budtenders become brand ambassadors for the products they’re partial to? As an extension of that, how many producers are mining their pool of local tenders before posting ads directed at the marketing graduates? I think we can all agree that passion for cannabis isn’t taught, but is inherit in the personality of enthusiasts.
My takeaways from working in this industry have been positive. Establishing those relationships with growers and seeing their products flourish in retail is rewarding – you can tell whose heart and soul goes into what’s brought to market. I work in oil and gas now and I tell you: I miss the industry and the Island, and will likely return to both.
Canadian bud will always have high global status, from coast-to-coast, because the people here really know how to deliver on some of the finest smoke around – it’s just part of our culture.
Uhrius Hartwell hails from Calgary and intends on advancing his work in the Canadian cannabis industry.
by Grow Up Conference | Jun 30, 2023 | Grow Opportunity, Media Partners
(Globe Newswire) Vancouver — Xebra Brands Ltd. announces today that it was not in a position to file its audited annual financial statements, management’s discussion and analysis and related officer certifications for the fiscal year ended February 28, 2023 on or before the filing deadline of June 28, 2023, as required under applicable Canadian securities laws.
Xebra has been delayed in meeting the deadline for its annual filings due to recent management changes. As a result, the company applied for a management cease trade order under National Policy 12-203 (NP 12-203). An MCTO has been granted by the company’s principal regulator, the British Columbia Securities Commission.
Xebra is working diligently with its auditors, Dale Matheson Carr-Hilton LaBonte LLP and expects to have the audit of the annual filings completed no later than July 15, 2023. Xebra will issue a news release once the annual filings have been filed. Now that the management changes have concluded, Xebra does not expect to experience delays with future filings.
Until Xebra files the annual filings, it will comply with the alternative information guidelines set out in NP 12-203 by issuing bi-weekly default status reports, in the form of news releases, for so long as the annual filings have not been filed.
by Grow Up Conference | Jun 30, 2023 | Grow Opportunity, Media Partners
Chilliwack, B.C. — A British Columbia health authority has issued a public warning after it says benzodiazepines were detected in vape juice sold in Chilliwack, B.C.
Fraser Health issued an overdose alert Thursday saying the juice that tested positive contained cannabis and suspected synthetic cannabinoids and was sold in refillable, unmarked and unbranded cartridges.
It did not specify where the product was sold.
The alert says reported side-effects include prolonged sedation, nausea, vomiting and blackouts.
Health Canada says benzodiazepines, or benzos, are a class of substances often used as sedatives and tranquillizers.
Fraser Health notes that in the event of an overdose, naloxone, the overdose-reversing treatment, won’t work unless an opioid is also present.
by Grow Up Conference | Jun 30, 2023 | Extraction Magazine, Media Partners
Supercritical fluid extraction (SFE) is an effective method to separate valuable compounds from plant matrices, with high efficiency and selectivity.
Supercritical fluids are highly compressed gasses which at a certain specific temperature and pressure behave half way between a gas and a liquid. Once reached the supercritical state, the extraction solvent density increases with the increase of the pressure, in turn enhancing the solubility of the extracted materials. [1]
SFE has been developed as a green alternative to other conventional extraction methods which usually involve large amounts of solvents and produce large volumes of wastes.
Moreover through SFE it is possible to conduct a selective extraction by accurately tuning pressure and temperature and preserving the volatiles of the extract and all the thermolabile molecules which can be damaged during conventional extraction processes. [2]
The process of SFE extraction can be divided into two steps:
- The plant material is solubilized with the solvent at the supercritical state;
- The extracted compounds are then recovered from the solvent to produce the end product.
Supercritical CO2
Carbon dioxide (CO2) is the most widely used solvent for SFE. This is because CO2 can relatively easily reach its critical temperature (31°C) and critical pressure (74 bar). Sometimes small amounts of a co-solvent such as methanol, ethanol or water can be added in order to increase the polarity of supercritical CO2 and to enhance the solubility of certain polar compounds.
SFE doesn’t leave behind solvent residues in the final extract. In fact at atmospheric pressure CO2 is a gas so all the solvent will evaporate leaving a purer final extract compared to other extraction methods.
In addition to that CO2 is non-toxic, odorless, tasteless, non-flammable and relatively cheap. SFE using CO2 as solvent is considered a green extraction method because the solvent can be reused: performing the extraction in a closed-loop system allows the recycling of the solvent that can be then stored in a tank till the next use.
Even if CO2 is a greenhouse gas, the extraction process removes it from the environment and once it is expelled back it doesn’t result in an increase of the greenhouse emissions. Due to its relatively low critical temperature and good safety profile, CO2 is largely used in food, essential oils, aromas and nutraceutical industries. [2]
Benefits of SFE Compared to Conventional Methods
- Control the extraction parameters such as temperature and pressure with direct impact on the solvent density, thus the extractants solubility;
- Improved selectivity of the target compound;
- Improved mass-transfer properties;
- Higher extraction yields;
- Shorter extraction time;
- Lower solvent residues in the final extract.
Cannabis and Supercritical CO2 Extraction
Cannabis plants can be successfully extracted with SFE technique using supercritical CO2 (scCO2) as solvent. In this particular state, CO2 is slightly non-polar. This feature is essential in order to efficiently extract cannabinoids, the main active phytoconstituents of cannabis.
Among cannabinoids the most well-known and desired are tetrahydrocannabinol (THC) and cannabidiol (CBD). The former is psychotropic, but has many potential therapeutic effects including analgesic, anti-anxiety, antiemetic among others. The latter, unlike THC, doesn’t alter perceptions and is a potential anti-inflammatory, neuroprotective, analgesic, anti-anxiety agent among other beneficial effects.
Cannabis plant material can be extracted while maintaining the integrity and the concentration of terpenes found in that specific sample. The whole process can be performed with the same solvent, on the same plant matter to selectively extract different components at different stages.
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The extraction yield of phytoconstituents is highly dependent on the pressure used during the process and the plant material starting composition. In some cases it is possible to add a co-solvent like ethanol to improve the extraction range.
SFE using CO2 as solvent is well-known for its ability to create a wide variety of products and full-spectrum extracts. Flavor, aromas and composition of a particular cannabis strain can be obtained efficiently using this technique. The common CO2 cannabis-derivatives produce: concentrates, edibles, topicals, vapes and tinctures.
How to Perform scCO2 Extraction?
- The operator can dry the extracted plant sample in order to reduce the amount of contained water that could lead to a reduced yield. Other procedures involve the freezing of the plant material to remove the moisture and to ease the disruption of cell walls thus the extraction of the active plant constituents. The plant material can be ground in order to increase the exposed surface to the solvent;
- Then he seals the extraction vessel and sets the pressure and temperature parameters. The liquefied CO2 at the supercritical state enters the extraction vessel and flows through the plant material extracting the phytocomponents;
- The extract enters the separation chamber. Here the CO2 returns to its gas state releasing the pressure and goes back to the extraction chamber in order to continue extracting all the molecules of interest. On the other hand the extracted substances drop out the gas stream and they are collected in a separate cup.
The selection of the right parameters when performing a scCO2 extraction is crucial in order to maximize the quality and the quantity of the final extract, reducing the post-processing procedures and obtaining an extract with the same composition found in the plant matter.
Extraction Equipment for Supercritical CO2 Extraction
This extraction technique is performed in a closed-loop system, where the solvent is stored in a sealed container and it can be recycled for other extraction runs. Depending on the scale of the operation, the budget for the project business, the types of desired final products and the size of the facility, various type of extraction equipment can be used.
The main variables to take into account for this type of extraction are:
- The high pressure of the system transforms the state of the solvent;
- The efficient heat delivery to change the solvent and extract temperature;
- The possibility of knowing the solvent temperature in order to finely tune the solvent density.
It is recommended to invest in a flow monitoring system and a solvent pump to check the entrance and rate of the solvent into the extraction vessel. Moreover the separation chamber can be adjusted in order to separate different components depending on the applied pressure, to create a variety of cannabis-derived products.
Disadvantages of Supercritical CO2 Extraction
The solvent requires a relatively high pressure in order to reach the supercritical state. This implies the fact that the machinery used to perform the extraction has to be built in order to sustain high pressure making it quite expensive.
The relatively high operating pressure results sometimes in the extraction of unwanted substances like fats, lipids and waxes. Often a further purification step is required in order to obtain a final product without unwanted residues.
References:
- Pimentel-Moral, Sandra; Borrás-Linares, Isabel; Lozano-Sánchez, Jesús; Arráez-Román, David; Martínez-Férez, Antonio; Segura-Carretero, Antonio (2018). Supercritical CO2 extraction of bioactive compounds from Hibiscus sabdariffa. The Journal of Supercritical Fluids, (), S0896844618305321–.doi:10.1016/j.supflu.2018.11.005
- https://www.tsijournals.com/articles/supercritical-fluid-extraction–a-review.pdf
by Grow Up Conference | Jun 30, 2023 | Cannabis News Wire, Media Partners
The United States cannabis sector is reaping the benefits of long-awaited tax relief as more states, currently standing at 20, have sanctioned legislation that grants exemptions to businesses from Section 280E of the federal tax law. During the spring, lawmakers in Illinois, Connecticut, New York, and New Jersey passed bills that will enable marijuana companies to reduce their business expenses from state income taxes, despite the fact that these businesses are still illegal under federal law.
The expected savings could be substantial for larger businesses, depending on the corporation tax rate imposed by each state.
Nevertheless, the state-level exemption does not impact the federal taxes that marijuana companies are liable to pay, and these businesses will still be prohibited from deducting expenses for national income taxes. Section 280E of the Internal Revenue Service (IRS) tax act prohibits marijuana businesses from claiming conventional business deductions due to the classification of the plant as a Schedule 1 substance under the federal CSA.
The Marijuana Policy Project (MPP), a Washington, D.C.-based advocacy group, claims that legislation to free businesses from the restrictions of 280E has been passed in 16 states where recreational cannabis use is allowed. In contrast, 280E has not been waived for the adult-use cannabis sector in Arizona, Alaska, Maine, Washington State, or Nevada, while Rhode Island’s attempts appear to have stagnated in a legislative committee. Also excluded from 280E under state tax regulations are medical marijuana businesses in Washington, D.C., Arkansas, Maine, Louisiana, and Hawaii.
Legislators are passing exemptions that let the cannabis industry operate and deduct business expenditures similarly to any other industry in recognition that the existing tax rates are unsustainable and that tax income may decrease further if businesses break down.
However, since corporate tax rates vary across states, the benefits derived from state exemptions will differ depending on the location of the companies.
For instance, whereas Illinois has a flat corporation tax rate of 9.5% for all businesses after decoupling from 280E in May, Nevada has no corporate tax. New Jersey permits deductions for both corporate company tax and gross income tax, while some jurisdictions could have limitations on deductibility.
Nevertheless, industry watchers are mostly optimistic about big federal-level improvements. The cannabis industry will likely pay an additional $1.8 billion in 2022’s federal taxes compared to noncannabis businesses, according to research done by Oregon-based Whitney Economics. This sum is anticipated to reach $2.1 billion this year. In the meantime, investors are closely monitoring the progress of President Joseph Biden’s administration, which recently declared its desire to examine and perhaps change the scheduling of cannabis.
With or without a scheduling change for marijuana, the pharmaceutical-grade formulations being developed by enterprises such as IGC Pharma Inc. (NYSE American: IGC) from cannabis may not be affected. This is because these companies have to adhere to an existing set of requirements overseen by the FDA, the regulator responsible for approving any drugs before they enter the healthcare market.
NOTE TO INVESTORS: The latest news and updates relating to IGC Pharma Inc. (NYSE American: IGC) are available in the company’s newsroom at https://cnw.fm/IGC
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