Select Page

Study Suggests SNRIs, SSRIs Reduce Effects of Psilocybin

Media Partners, Psychedelic News Wire

This post is presented by our media partner Psychedelic News Wire
View the original article here.

Findings from a recent study have revealed that SSRI and SNRI use may weaken the effects of psilocybin (magic mushrooms). The researchers were specifically interested in the extent to which antidepressants could diminish the effects of psilocybin when they were taken alongside the psychedelic and after antidepressant use is halted.

Psychedelics are predicted to revolutionize the psychiatric industry in a major way due to their purported mental health benefits. A series of studies have found that psychedelic drugs such as psilocybin, MDMA and LSD may be able to treat mental conditions  anxiety, depression, post-traumatic stress disorder, and even eating disorders.

If the FDA approves the use of psychedelic-based treatments, psychedelics could replace selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) as primary psychiatric medications.

Psilocybin has proven to be especially effective at treating major depressive disorder and treatment-resistant depression, offering patients in clinical trials relatively long-term relief with barely any serious side effects. Given the increasing mainstream popularity of psilocybin, the new study was designed to determine how the psychedelic would react with traditional antidepressants.

The team found that SNRIs and SSRIs may have a dampening effect on psilocybin, which could diminish the psychedelic’s effects for up to three months after the patient stops taking antidepressants. The researchers conducted an online retrospective poll of 2,153 people who had taken antidepressants while using psilocybin and individuals who had taken magic mushrooms within 24 hours of discontinuing antidepressant use.

The 611 individuals who reported using psilocybin while taking conventional antidepressants said that psilocybin’s effect was weaker than they expected. Members of this group indicated that they were also on either bupropion, SSRIs, or SNRIs when they used psilocybin. The remaining 1,542 individuals who had stopped using antidepressants at the time they took psilocybin also reported weakened effects.

Interestingly, the probability of experiencing weaker psilocybin effects was not that different between people who had ceased antidepressant use a week before taking psilocybin and people who had stopped taking antidepressants three to six months before using psilocybin. Even individuals who had stopped taking antidepressants several months prior experienced weaker effects, indicating that antidepressants take some time to clear out of the system completely.

The researchers concluded that SSRI/SNRI antidepressants can dampen the effects of psilocybin while nonserotonergic antidepressants don’t seem to have a similar dampening effect on psilocybin. These findings could have implications for subsequent psilocybin clinical studies depending on whether the participants are taking antidepressants or have stopped antidepressant use in the recent past.

Companies that are studying various psychedelics with a view to developing medicines from them, such as Seelos Therapeutics Inc. (NASDAQ: SEEL), are likely to bring to light even more insights into how these substances work and how they could interact with other medications.

About PsychedelicNewsWire

PsychedelicNewsWire (PNW) is a specialized content distribution company that (1) aggregates and distributes news and information on the latest developments in all aspects and advances of psychedelics and their use, (2) creates PsychedelicNewsBreaks designed to quickly update investors on important industry news, (3) leverages a team of expert editors to enhance press releases for maximum impact, (4) assists companies with the management and optimization of social media across a range of platforms, and (5) delivers unparalleled corporate communication solutions. PNW stays abreast of the latest information and has established a reputation as the go to source for coverage of psychedelics, therapeutics and emerging market opportunities. Our team of seasoned journalists has a proven track record of helping both public and private companies gain traction with a wide audience of investors, consumers, media outlets and the general public by leveraging our expansive dissemination network of more than 5,000 key syndication outlets. PNW is committed to delivering improved visibility and brand recognition to companies operating in the emerging markets of psychedelics.

To receive instant SMS alerts, text “Groovy” to 844-397-5787 (U.S. Mobile Phones Only)

For more information please visit https://www.psychedelicnewswire.com

Please see full terms of use and disclaimers on the PsychedelicNewsWire website applicable to all content provided by PNW, wherever published or re-published: https://www.psychedelicnewswire.com/Disclaimer

Do you have questions or are you interested in working with PNW? Ask our Editor

PsychedelicNewsWire (PNW)
San Francisco, California
www.psychedelicnewswire.com
415.949.5050 Office
Editor@PsychedelicWire.com

PsychedelicNewsWire is part of the InvestorBrandNetwork.

This post was originally published by our media partner here.

Grow Up Toronto – May 27-29, 2024
Delta Hotels Toronto Airport & Conference Centre

Grow Up Alberta – Sept. 29 – Oct. 1, 2024
Edmonton Convention Centre • Edmonton, AB

News from Grow Up Media partners