Scientists studying the clinical applications of psychedelics inevitably find their way to ayahuasca shamanism and the role of natural mind-altering substances in Indigenous spirituality and religious practice. In a field of study where science and religion can truly co-exist, researchers and non-Indigenous people must be mindful of honouring the traditions of sacred plants as they attempt to build a bridge between Native cultures and the efficacy of their medicine. This session will consider the traditional use of psychedelics and the reciprocity that must come with adapting it.